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Skeletal System

What is the functional relationship between the integumentary and skeletal systems? How does failure to maintain homeostasis in the integumentary system affect bone formation and remodeling processes? Be sure to discuss how the different types of bone cells respond to different factors (e.g., ions, hormones, cellular signaling molecules, etc.) and what the driving force behind maintaining homeostasis in the bone remodeling process. Describe the pathogenesis of osteoporosis and explain why it is considered a multifactorial disease. How do current therapies address these failures to maintain homeostasis and ameliorate the effects of osteoporosis?

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